Publications

• Hu Xu*, Tianyao Li*, Min Li,*, Jingxin Zhang, Ziwei Zhang, Yi Weng, Dengwang Luo, Chao Yang, Jing Guo, Yongqin Liu, Zhang Yue, Jun Zhang, Keyu Sun, Jianxun Qi, George F. Gao#, Guangyu Zhao#, Yuhong Cao#, “Modular Assembly of Lipid Nanoparticles for Targeted mRNA Therapeutics and Vaccines“, Submitted.

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• Xiangyu Ren, Yi Weng, Ziwei Zhang, Guangjin Pan and Yuhong Cao*, “Nanopore-Based Electroporation Enables High-Efficiency, Rapid RNA-Mediated Reprogramming of Primary Fibroblasts into Human iPSCs“, Under Revision. 

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• Dengwang Luo, Ziwei Zhang, Jing Guo, Qian Deng, Daming Wang*, Jieli Zhang, Arong Huang, Qinghao Cao, Jiangnan Zheng, Yingjin Yuan, Yuhong Cao*, "A Comprehensive Lateral Flow Strip Assay for On-Site mRNA Vaccine Quality Control in Decentralized Manufacturing", Under Revsion. ​

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• Yiwen Liao, Li‐Mei Zhang, Dawei Xu, Qinghao Cao, Hang Wang, Xiangyu Ren, Yong-Guan Zhu†, Yuhong Cao†, "Nano-encapsulating nitrogen fixing bacteria facilitates stable colonization and function on rice leaves", Under Revision. 

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• Tianyao Li*, Jingxin Zhang*, Yuxuan Han, Hu Xu, Qinghao Cao, Jing Guo#, Yuhong Cao#, "Engineering Internal Architecture of Lipid Nanoparticles to Promote Efficient mRNA Endosomal Release", Under Revision.

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• Ziwei Zhang*, Weiyu Li *, Dengwang Luo, Xiushuang Yuan, Li Yu, Yuhong Cao#, “Mitigating cellular dysfunction through contaminant reduction in synthetic circRNA for high-efficiency mRNA-based cell reprogramming”, Advanced Science, 2025, 2416629,DOI: 10.1002/advs.202416629.

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• Zhujiang Liu#, Jingkun Zhang#, Yao Cai, Hang Wang, Mingjie Luo, Jiayang Li, Hong Yu, Xiangbing Meng*, Yuhong Cao*," Improving Seed Shattering Resistance in Wild O. alta Rice with Mesoporous Silica Nanoparticle Delivery Systems“, Nano Letters, https://doi.org/10.1021/acs.nanolett.4c02297，Cover Story. ​

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• Yao Cai, Zhujiang Liu#, Huang Wang, Huan Meng, Yuhong Cao#，“Mesoporous silica nanoparticles mediate siRNA delivery for long-term multi-gene silencing in intact plants“ Advanced Science, 2024, 11, 2301358,DOI: 10.1002/advs.202301358.

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• Yiwen Liao, Dawei Xu, Yuhong Cao#, Yongguan Zhu, “Advancing Sustainable Agriculture: Enhancing Crop Nutrition with Next-Generation Nanotech-Based Fertilizers”, Nano Research, 2023, https://doi.org/10.1007/s12274-023-6284-8.

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• Xiushuang Yuan*, Zhanfeng Wu*, Jing Guo, Tianyao Li, Qinghao Cao, Xiangyu Ren, Han Fang, Dawei Xu#, Yuhong Cao#，“Natural wood-derived macroporous cellulose for highly efficient and ultrafast elimination of double-stranded RNA from in vitro-transcribed mRNA“, Advanced Materials, 2023, https://doi.org/10.1002/adma.202303321.​

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• Dengwang Luo*, Zhanfeng Wu*, Daming Wang, Jieli Zhang, Fei Shao, Shuo Wang, Stefano Cestellos-Blanco, Dawei Xu#, Yuhong Cao#，“Lateral flow immunoassay for rapid and sensitive detection of dsRNA contaminants in in vitro-transcribed mRNA products“. Molecular Therapy-Nucleic Acids, 2023, 32, 445-453.

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• Xiaodong Xie, Jinhong Jiang, Xiangsheng Liu, Yuhong Cao, Jiulong Li, Tian Xia, Huan Meng, "Interleukin-10 plasmid delivery by polymeric nanocarrier shows efficient and safe tissue repair in acute muscle damage models in mice". Nano Today, 2022, 46, 101544.

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• Dawei Xu, Samuel Lim, Yuhong Cao, Abner Abad, Aubrey Nayeon Kang and Douglas S.Clark, "Filamentous Chaperone Protein-Based Hydrogel Stabilizes Enzymes Against Thermal Inactivation". Chemical Communications, 2021, 57, 5511-5513.

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• Yuhong Cao, George F. Gao,"mRNA Vaccines: A Matter of Delivery". EClinicalMedicine, 2021,32,100746.

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• Huan Zhang#,Yu.hong Cao# (Equal Contribution), Dawei Xu, Natalie S. Got, Gozde S. Demirer, Stefano Cestellos-Blanco, Yuan Chen, Makita Landry*, Peidong Yang*, “Gold Nanoclusters Meditated Delivery of siRNA to Intact Plant Cells for Efficient Gene Knockdown”. Nano Letters, 2021, 21, 13, 5859–5866.

 

• Zhongwen Chen#, Yuhong Cao# (Equal contribution), Chun-Wei Lin, Steven Alvarez, Dongmyung Oh, Peidong Yang*, Jay Groves*, “Nanopore Mediated Protein Delivery Enabling 3-color Single Molecule Tracking in Living Cells”, Proceedings of the National Academy of Sciences, 2021, Vol. 118 No. 5 e2012229118.

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• Yude Su*, Stefano Cestellos-Blanco*, Ji Min Kim*, Yue-xiao Shen, Qiao Kong, Dylan Lu, Chong Liu, Hao Zhang, Yuhong Cao, Peidong Yang, “Close-packed nanowire-bacteria hybrids for efficient solar-driven CO2 fixation”, Joule, 4, 800–811 (2020).

 

• Yuhong Cao, Enbo Ma, Stefano Cestellos-Blanco, Bei Zhang, Ruoyi Qiu, Yude Su, Jennifer A. Doudna, and Peidong Yang, “Nontoxic Nanopore Electroporation for Effective Intracellular delivery of Biological Macromolecules”, Proceedings of the National Academy of Sciences, Apr 2019, 116 (16) 7899-7904.

 

• Yuhong Cao, Haodong Chen, Ruoyi Qiu, Enbo Ma, Richard Lewis, Joseph C. Wu, Nicholas A. Melosh, “Universal Biomolecules Intracellular Delivery with Dosage Quantitative Control” Science Advances, 2018, 4, 10.

 

• Gen He, Hui-Jiuan Chen, Di liu, Yuping Feng, Chengduan Yang, Tian Hang, Jiangming Wu, Yuhong Cao, Xie Xi, ‘Fabrication of Various Structures of Nanostraw Arrays and Their Applications in Gene Delivery” Advanced Materials Interfaces, 2018, 5, 1701535.

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• Tian Hang, Hui-Jiuan Chen, Ji Wang, Di-An Lin, Jiangming Wu, Yuhong Cao, Chengduan Yang, Chenglin Liu, Shuai Xiao, Meilin Gu, Shuolin Pan, Mei Wu, Xi Xie “Nanospikes Functionalization as a Universal Strategy to Disperse Hydrophilic Particles in Non-polar Media" Nanotechnology, 2018, 29, 18. 

 

• Bozhi Tian, Shuai Xu, John Rogers, Stefano Cestellos-Blanco, Peidong Yang, Joao L Carvalho-de-Souza, Francisco Bezanilla, Jia Liu, Zhenan bao, Martin Hjort, Yuhong Cao, Nicholas Melosh, Guglielmo Lanzani, Fabio Benfenati, Giulia Galli, Francois Gygi, Rylan Kautz, Alon A Gorodetsky, Samuel S Kim, Timothy K Lu, Polina Anikeeva, Michal Cifra,Ondrej Krivosudsky, Daniel Havelka and Yuanwen Jiang. “Roadmap on semiconductor-cell biointerfaces” Physical Biology, 2018, 15, 031002.

 

• Yuhong Cao, Martin Hjort, Haodong Chen, Fikri Birey, Sergio Leal-Ortiz, Crystal M. Han, Juan G. Santiago, Sergiu P. Pașca, Joseph C. Wu, Nicholas A. Melosh, “Non-Destructive Nanostraw Intracellular Sampling for Longitudinal Cell Monitoring” Proceedings of the National Academy of Sciences, 2017, 114 (10) E1866-E1874.[Highlight by Science, Cozzarelli Award by National Academy of Sciences (Annual best paper of PNAS)].

 

• Alexander M. Xu, Derek Wang, Peyton Shieh, Yuhong Cao, Nicholas A. Melosh, “Direct Intracellular Delivery of Cell-Imermeable Probes of Protein Glycosylation by Using Nanostraws” ChemBioChem, 2017,18,7.

 

• Yuling Liu, Yuhong Cao, Xi Xie, Meiwan Chen, Hui Li, “Redox-sensitive pluronic F127-tocopherol micelles: synthesis, characterization and cytotoxicity evaluation” ICMJE, 2017, 12, 2635-2644.

 

• Cade B. Fox, Yuhong Cao, Cameron L. Nemeth, Hariharasudhan D. Chirra, Rachel W. Chevalier, Alexander M. Xu, Nicholas A. Melosh, Tejal A. Desai “Fabrication of sealed nanostraw microdevices for oral drug delivery” ACS Nano, 2016, 10, 5873-5881.

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• Xi Xie, Alex Xu, Sergio Leal-Ortiz, Yuhong Cao, Craig Garner, Nicholas A. Melosh, “Nanostraw-electroporation system for highly efficient intracellular delivery and transfection.” ACS Nano, 2013, 7, 4351−4358.